IVF treatment for Unexplained Infertility

Unexplained Infertility refers to a condition where the reason of infertility in the male/female or both partners is not known or found even after completing all the tests (like ultrasound, blood test, male semen test and so forth which are required to diagnose the cause of the problem in the infertile patients.

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Basic Infertility Evaluation

• Medical history of female and male partner.

• physical examination

• Semen analysis

• Detection of ovulation

• Ovarian reserve (if indicated)

• Patency of fallopian tubes

• Uterine evaluation

• Preconception counseling and lab testing

There are 3 Major Causes of Unexplained Infertility:

That’s why when the infertile patients come to us with unexplained infertility, we carefully evaluate all cases of unexplained infertility and look again for the causes and in our opinion there can be the following causes:

Tubal Disease– In case of tubal diseases, high percentage of misdiagnosis is because of interpretation and limitation of Hysterosalpingography. We at Nandanee IVF look at the tube not only for obstruction but from the point of the functionality of the tube which could be compromised due to any disease. Our Endeavour is to find the disease associated with the tube.

POA (Premature Ovarian aging/failure) – The Ovarian age is a very important factor in unexplained infertility. When women are born, they have approximately 300,000 follicles and in every decade this number decline by half. In terms of decline in the follicular number, female fertility declines until the age of 37 years, when around 25,000 follicles only left. Sometimes there can be the premature decline in the number of eggs. This can be due to several reasons such as family history, radiation damage, any previous adenexal or ovarian  surgery, chemotherapy or any other such reason.

Immunological Infertility– Some people have argued that there can be immunological reasons behind unexplained infertility but this is not fully established. We do not agree with this explanation. We have carried out a lot of research by giving immune suppressants during the IVF cycle without any effect. No clinic has demonstrated positive results in clinic based trials.

Other Causes of unexplained infertility can be Endometriosis, Aging, and/or morbidity effects of infections like tuberculosis.

Management Unexplained Infertility

• Normal fertility evaluation but failure to conceive

• Emperical treatment

• ovulation induction with ovulation inducing agents (clomiphene or letrozole) and IUI with    gonadotropin therapy may be beneficial

• May encourage couples to move on to IVF

• IUI Provides insight to the possible cause of the couple’s infertility and overcome undetected defects

Some Facts About Unexplained Infertility Treatment

·       Only 20-30% case of infertility comes under this category. It is quite frustrating for the couple who cannot get any answer for their predicament. But there is no reason to lose heart, as assisted reproductive technology has given us many more options to have baby of your own. You must discuss this with us at Nandanee IVF & Fertility Centre.

·       Usually, the chances of getting pregnant of fertile patients are 20%, whereas, in infertile patients, it is only 2-3% even with medication. So it’s really hard for them to conceive. But the doctors suggest that before going on medication a couple should try at least six months to one year before consulting a specialist.

·       At least 6% of women coming to us are suffering from sensitivity or allergy to gluten, a protein in wheat, rye, and barley. Infertility in these women is due to this Celiac disease which causes the leaky gut syndrome. This, in turn, cases several autoimmune reactions and blocks several normal functions, including some reproductive functions leading to infertility.